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Congresso Brasileiro de Microbiologia 2023
 		Resumo: 630-2

630-2

SARS-COV-2 INFECTION IN HEAD AND NECK CANCER PATIENTS AND ITS CLINICAL OUTCOME

Autores:
Priscila Marinho de Abreu (PPGCO - PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS ODONTOLÓGICAS, UFES - Universidade Federal do Espírito Santo) ; Roberta Ferreira Ventura Mendes (PPG-RENORBIO - PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA DA REDE NORDESTE, UFES - Universidade Federal do Espírito Santo) ; Giuliano Lozer Bruneli (PPGCO - PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS ODONTOLÓGICAS, UFES - Universidade Federal do Espírito Santo) ; Jhully Oliveira Ferreira (UFES - DEPARTAMENTO DE PATOLOGIA) ; Camila Batista Daniel (PPGBIOTEC - PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA , UFES - Universidade Federal do Espírito Santo) ; Jéssica Graça Sant'anna (PPGBIOTEC - PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA , UFES - Universidade Federal do Espírito Santo) ; Brena Ramos Athaydes (PPGBIOTEC - PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA , UFES - Universidade Federal do Espírito Santo) ; Mariane Vedovatti Monfardini Sagrillo (PPGDI - PROGRAMA DE PÓS-GRADUAÇÃO EM DOENÇAS INFECCIOSAS, UFES - Universidade Federal do Espírito Santo) ; José Roberto Vasconcelos de Podestá (PPDPCCP - Programa de Prevenção e Detecção Precoce do Câncer de Boca ) ; Jerfeson Lenzi (PPDPCCP - Programa de Prevenção e Detecção Precoce do Câncer de Boca ) ; Evandro Duccini de Souza (PPDPCCP - Programa de Prevenção e Detecção Precoce do Câncer de Boca ) ; Marco Homero de Sá Santos (EBSERH - Hospital Universitário Cassiano Antônio Moraes) ; Ricardo Mai Rocha (PPDPCCP - Programa de Prevenção e Detecção Precoce do Câncer de Boca , EBSERH - Hospital Universitário Cassiano Antônio Moraes) ; Liliana Cruz Spano (PPGDI - PROGRAMA DE PÓS-GRADUAÇÃO EM DOENÇAS INFECCIOSAS) ; Sandra Ventorin Von Zeidler (UFES - Universidade Federal do Espírito Santo, PPG-RENORBIO - PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA DA REDE NORDESTE, PPGBIOTEC - PROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA , PPGCO - PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS ODONTOLÓGICAS)

Resumo:
Since the onset of the first cases of COVID-19 in 2019, with its subsequent declaration of a pandemic by the WHO in March 2020, several surveys were conducted to understand the relationship between the disease and cancer patients admitted to different treatments such as surgery, chemotherapy, and radiotherapy. Most of these studies have focused on the response to hospital treatment in patients with COVID-19. However, little was known about the association between oncological treatment in patients with head and neck cancer (HNC) and mortality due to COVID-19. This study aimed to analyze the COVID-19 impact on prognosis, comparing the clinical outcome of patients infected and non-infected with SARS-CoV-2. The diagnosis of SARS-CoV-2 was performed using the technique of reverse transcription and amplification by real-time polymerase chain reaction (RT-PCR) of patients who attended on Department of Head and Neck Surgery of Hospital Santa Rita de Cássia (HSRC) between October 2020 and November 2021, before the surgical procedure. To compare the clinical outcomes of patients for the presence of SARS-CoV-2 infection, well-established prognostic factors were used for patients with HNC, such as investigation of pre-existing comorbidities and viral load analysis of patients referred for surgery. Of the 194 patients recruited with a diagnosis of HNC, 99 underwent treatment surgery and were followed up for up to 20 months to evaluate the prognosis. Of the 99 patients, 8.1% (8/99) were infected with SARS-CoV-2. However, no difference was observed difference in overall survival when considering only the status of SARS-CoV-2 infection (p = 0.086). Viral load showed no association with vital status (p = 0.456). Therefore, we conclude that SARS-CoV-2 infection did not influence the overall survival of patients with HNC included in this study. Financial support: FAPES, CAPES.

Palavras-chave:
 SARS-CoV-2, COVID-19, head and neck cancer


Agência de fomento:
Fundação de Amparo à Pesquisa e Inovação do Espírito Santo – FAPES; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – CAPES.